March 7, 2013 - The Diagnostic Ability of Companion Animals

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A study recently published in the British Medical Journal reports that dogs can be used to detect human infections. The highly developed olfactory sense of dogs could identify Clostridium difficile (C-diff) infections in stool samples as well as the air surrounding patients in the hospital environment with a high degree of accuracy. Clostridium difficile is a bacteria that is extremely resistant to antibiotics and is responsible for a rising number of hospital infections.


This phenomenon has potential as a quick screening procedure that could detect infections much earlier the standard diagnostic testing which is slow and expensive. Dogs also appear to have the ability to detect various types of cancer.

Cliff, a two-year-old male Beagle was tested on 50 C-diff positive and 50 C-diff negative stool samples. He managed to correctly identify all 50 positive samples and 47 of the 50 negative samples. This equates to 100 percent sensitivity and 94 percent specificity (sensitivity measures the proportion of positives correctly identified, while specificity measures the proportion of negatives correctly identified).

In a hospital ward Cliff managed to correctly identify 25 of 30 cases (83 percent sensitivity) and 265 of 270 negative controls (98 percent specificity) - In fewer than 10 minutes.

Learn more below, or at the original article here.

Comment from ABC: This is another good example of how we can learn a lot from our animals if we learn to appreciate their innate wisdom.


 

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The role of animals in hospital infections

(NaturalNews) In this high-tech world, sometimes it’s better to rely on a low-tech solution or, in this case, no tech.
 
A new study to be published in the Christmas issue of the British Medical Journal found that dogs can be used to sniff out Clostridium difficile, or C-diff, the element that is responsible for a rising number of hospital infections that are extremely resistant to antibiotics.

The olfactory sense of dogs can be used to identify C-diff infections in stool samples as well as the air surrounding patients in the hospital environment, all with a high degree of accuracy, researchers said.

The journal said current findings support earlier conclusions that dogs are capable of detecting various types of cancer as well, and may have potential for screening hospital wards to help prevent C-diff outbreaks.

The infectious C-diff occurs most commonly in older patients who have recently finished a course of antibiotics in the hospital. But the infections can also begin in the community, especially in nursing homes and other skilled facilities. Symptoms of the infection can range from mild diarrhea to a life-threatening bowel inflammation.

Some questions remain, but early results are promising

Early detection of the infection is important if doctors hope to contain its spread, but diagnostic tests confirming it are slow (and expensive), which can delay treatment for as much as a week.

Researchers said that diarrhea as a result of a C-diff infection has a certain smell, and that dogs - with their superior olfactory capabilities - likely could detect it much better, in comparison with humans. That supposition prompted scientists in the Netherlands to see if dogs could be trained to sniff out C-diff.

Scientists used a two-year-old male Beagle (named Cliff) that had been trained by a professional instructor to spot C-diff in stool samples and in patients who had contracted the infection. Cliff was taught to either lay down or sit when he detected the specific scent.

Following two months of training, Cliff’s detection capability was formally tested on 50 C-diff positive and 50 C-diff negative stool samples, said scientists. He managed to correctly identify all 50 positive samples and 47 of the 50 negative samples.

The results equate to 100 percent sensitivity and 94 percent specificity (sensitivity measures the proportion of positives correctly identified, while specificity measures the proportion of negatives correctly identified).

Cliff was then taken to two hospital wards to conduct further detection tests in a live environment. The dog managed to correctly identify 25 of 30 cases (83 percent sensitivity) and 265 of 270 negative controls (98 percent specificity). Researchers added that the dog was efficient and quick, managing to screen a complete hospital ward for the presence of patients infected with C-diff in fewer than 10 minutes.

 

Early detection certainly possible

Scientists admitted there were some limitations to the study, such as the unpredictability of using an animal as a diagnostic tool, as well as the possibility that the dog itself could spread infections. Other scientists say other unanswered questions remain.

Still, they note that the study demonstrates that training a dog to detect C-diff infection with a high degree of accuracy, both in samples of stool and in patients who are hospitalized and could contract the infection.

"Early detection could overcome common diagnostic delays (lack of clinical suspicion, delays in sampling stool, and laboratory procedures) and lead to prompt hygienic measures and treatment," the researchers concluded. "This could have potential for C. difficile infection screening in healthcare facilities and thus contribute to C. difficile infection outbreak control and prevention."

See the original article here

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